MK2 signaling: lessons on tissue specificity in modulation of inflammation

J Invest Dermatol. 2010 Feb;130(2):342-4. doi: 10.1038/jid.2009.372.

Abstract

MK2 is a promising candidate for treating inflammation. Mice deficient in MK2 were studied in models of inflammation to see whether MK2 could be a useful target in inflammatory skin disease. Surprisingly, MK2 played only a minor role in skin inflammation, indicating that modulation of cell signaling gives different results depending on the models of inflammation and target organs that are studied.

Publication types

  • Comment

MeSH terms

  • Animals
  • Gene Expression Regulation
  • Humans
  • Inflammation / genetics*
  • Intracellular Signaling Peptides and Proteins / genetics
  • Intracellular Signaling Peptides and Proteins / physiology*
  • Mice
  • Models, Biological
  • Protein Serine-Threonine Kinases / genetics
  • Protein Serine-Threonine Kinases / physiology*
  • Signal Transduction
  • Skin / metabolism*
  • Skin Physiological Phenomena
  • p38 Mitogen-Activated Protein Kinases / metabolism

Substances

  • Intracellular Signaling Peptides and Proteins
  • MAP-kinase-activated kinase 2
  • Protein Serine-Threonine Kinases
  • p38 Mitogen-Activated Protein Kinases