Cytotoxic neoclerodane diterpenoids from Scutellaria barbata

J Nat Prod. 2010 Feb 26;73(2):233-6. doi: 10.1021/np900309p.

Abstract

Seven new neoclerodane diterpenoids, scutebatas A-G (1-7), have been isolated from Scutellaria barbata. Compounds 1-3 possess a rare alpha-hydroxy group in their alpha,beta-unsaturated lactone rings. Their structures were elucidated by spectroscopic analysis, and the relative configuration of scutebata A was deduced using ROESY data and the computational DFT method. Compounds 1, 2, 4, 5, and 6 were evaluated for in vitro cytotoxicity against six human cancer cell lines: HL-60, SMMC-7721, A-549, SK-BR-3, CACO-2, and PANC-1. Scutebata A (1) showed weak cytotoxicity against SK-BR-3 with an IC(50) value of 15.2 muM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Diterpenes / pharmacology*
  • Diterpenes, Clerodane
  • Drug Screening Assays, Antitumor
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology*
  • HL-60 Cells
  • Humans
  • Molecular Structure
  • Scutellaria / chemistry*

Substances

  • Antineoplastic Agents, Phytogenic
  • Diterpenes
  • Diterpenes, Clerodane
  • Drugs, Chinese Herbal
  • neoclerodane