Objective: To summarize the combination profile of hepatitis B markers by age and immunization history of Chinese.
Methods: Population of age 1-59 years were sampled from 160 counties of National Disease Surveillance in 31 provinces by multi-stage random sampling method. Demographic information and hepatitis B vaccination history was collected by questionnaire, and 2-4ml serum sample was taken for testing HBsAg, Anti-HBs and Anti-HBc by ELISA method.
Results: 16 combinations of hepatitis B markers (HBsAg, Anti-HBs, Anti-HBc, HBeAg and Anti-HBe) were found during the testing, anti-HBs was mainly found among 1-4 years old children, accounted 69.77%. Among 15-59 years, negative markers were mainly profile. Among immunized population, the older, the lower rate of anti-HBs, while among un-immunized population, except negative for all markers and anti-HBs were observed, Infected markers was account for high proportion.
Conclusion: The profile could be used for guiding the laboratory testing by different epidemiologic characteristics, and can provide information for reference.