Synthesis of functionalized 1,2,4-triazole-3-thiones from ammonium isothiocyanate, acid chlorides, and arylhydrazines

Issa Yavari; Faezeh Shirgahi-Talari; Zinatossadat Hossaini; Maryam Sabbaghan; Samereh Seyfi

doi:10.1007/s11030-009-9218-9

Synthesis of functionalized 1,2,4-triazole-3-thiones from ammonium isothiocyanate, acid chlorides, and arylhydrazines

Mol Divers. 2010 Nov;14(4):763-6. doi: 10.1007/s11030-009-9218-9. Epub 2010 Jan 16.

Authors

Issa Yavari¹, Faezeh Shirgahi-Talari, Zinatossadat Hossaini, Maryam Sabbaghan, Samereh Seyfi

Affiliation

¹ Department of Chemistry, Tarbiat Modares University, PO Box 14115-175, Tehran, Iran. yavarisa@modares.ac.ir

PMID: 20077003
DOI: 10.1007/s11030-009-9218-9

Abstract

An efficient synthesis of 1-aryl-5-aryl(alkyl)-1,2-dihydro-3H-1,2,4-triazole-3-thiones via reaction between ammonium thiocyanate, acid chlorides, and arylhydrazines is described.

MeSH terms

Acids / chemistry*
Chlorides / chemistry*
Cyclization
Hydrazines / chemistry*
Isothiocyanates / chemistry
Models, Biological
Quaternary Ammonium Compounds / chemistry
Thiocyanates / chemistry*
Thiones / chemical synthesis*
Triazoles / chemistry

Substances

Acids
Chlorides
Hydrazines
Isothiocyanates
Quaternary Ammonium Compounds
Thiocyanates
Thiones
Triazoles
1,2,4-triazole
thiocyanic acid