Abstract
Bioassay-guided fractionation of the culture broth of Aspergillus sp. FN070449 (KCTC 26428) using a DPPH (2,2-diphenyl-1-picrylhydrazyl) assay led to the isolation of two compounds: reticulone (1) and reticulol (2). Their chemical structures were elucidated on the basis of UV, IR, NMR, and MS spectroscopic analysis. Compound 1 exhibited more potent free radical scavenging activity on ABTS.+ (2,2'-azino-bis [3-ethylbenzthiazoline-6-sulphonic acid]) and DPPH radicals than did butylated hydroxyanisole (BHA) and caffeic acid.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aspergillus / metabolism*
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Benzaldehydes / chemistry
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Benzaldehydes / isolation & purification
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Benzaldehydes / metabolism*
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Benzothiazoles / metabolism
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Biphenyl Compounds / chemistry
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Butylated Hydroxyanisole / metabolism
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Caffeic Acids / metabolism
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Coumarins / chemistry
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Coumarins / isolation & purification
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Coumarins / metabolism
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / isolation & purification
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Free Radical Scavengers / metabolism*
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Industrial Microbiology
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Isocoumarins
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Magnetic Resonance Spectroscopy
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Oxidative Stress
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Picrates / chemistry
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Sulfonic Acids / metabolism
Substances
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Benzaldehydes
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Benzothiazoles
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Biphenyl Compounds
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Caffeic Acids
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Coumarins
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Free Radical Scavengers
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Isocoumarins
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Picrates
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Sulfonic Acids
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reticulone
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Butylated Hydroxyanisole
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reticulol
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2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid
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1,1-diphenyl-2-picrylhydrazyl
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caffeic acid