Reticulone, a novel free radical scavenger produced by Aspergillus sp

J Microbiol Biotechnol. 2009 Dec;19(12):1573-5. doi: 10.4014/jmb.0906.06033.

Abstract

Bioassay-guided fractionation of the culture broth of Aspergillus sp. FN070449 (KCTC 26428) using a DPPH (2,2-diphenyl-1-picrylhydrazyl) assay led to the isolation of two compounds: reticulone (1) and reticulol (2). Their chemical structures were elucidated on the basis of UV, IR, NMR, and MS spectroscopic analysis. Compound 1 exhibited more potent free radical scavenging activity on ABTS.+ (2,2'-azino-bis [3-ethylbenzthiazoline-6-sulphonic acid]) and DPPH radicals than did butylated hydroxyanisole (BHA) and caffeic acid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aspergillus / metabolism*
  • Benzaldehydes / chemistry
  • Benzaldehydes / isolation & purification
  • Benzaldehydes / metabolism*
  • Benzothiazoles / metabolism
  • Biphenyl Compounds / chemistry
  • Butylated Hydroxyanisole / metabolism
  • Caffeic Acids / metabolism
  • Coumarins / chemistry
  • Coumarins / isolation & purification
  • Coumarins / metabolism
  • Free Radical Scavengers / chemistry
  • Free Radical Scavengers / isolation & purification
  • Free Radical Scavengers / metabolism*
  • Industrial Microbiology
  • Isocoumarins
  • Magnetic Resonance Spectroscopy
  • Oxidative Stress
  • Picrates / chemistry
  • Sulfonic Acids / metabolism

Substances

  • Benzaldehydes
  • Benzothiazoles
  • Biphenyl Compounds
  • Caffeic Acids
  • Coumarins
  • Free Radical Scavengers
  • Isocoumarins
  • Picrates
  • Sulfonic Acids
  • reticulone
  • Butylated Hydroxyanisole
  • reticulol
  • 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid
  • 1,1-diphenyl-2-picrylhydrazyl
  • caffeic acid