Abstract
The regulated local synthesis of PtdIns4P and PtdIns(4,5)P(2) is crucial for TGN (trans-Golgi network)-plasma membrane trafficking. The activity of PI4Kbeta (phosphoinositide 4-kinase IIIbeta) at the Golgi membrane is a first mandatory step in this process. In addition to PI4Kbeta activity, elevated Ca(2+) levels are also needed for the exit of vesicles from the TGN. The reason for this Ca(2+) requirement is at present unclear. In the present review, we discuss the role of neuronal Ca(2+)-sensor proteins in the regulation of PI4Kbeta and suggest that this regulation might impose a need for elevated Ca(2+) levels for a late step of vesicle assembly.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Biological Transport / physiology*
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Calcium / metabolism*
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Calmodulin / metabolism
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Cell Membrane / metabolism*
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Golgi Apparatus / metabolism*
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Golgi Apparatus / ultrastructure
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Isoenzymes / antagonists & inhibitors
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Isoenzymes / metabolism
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Minor Histocompatibility Antigens
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Phosphotransferases (Alcohol Group Acceptor) / antagonists & inhibitors
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Phosphotransferases (Alcohol Group Acceptor) / metabolism
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Transport Vesicles / metabolism
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trans-Golgi Network / metabolism*
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trans-Golgi Network / ultrastructure
Substances
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Calmodulin
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Isoenzymes
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Minor Histocompatibility Antigens
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Phosphotransferases (Alcohol Group Acceptor)
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phosphatidylinositol phosphate 4-kinase
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Calcium