SUMO and ubiquitin modifications during steroid hormone synthesis and function

Biochem Soc Trans. 2010 Feb;38(Pt 1):54-9. doi: 10.1042/BST0380054.

Abstract

Steroid hormones control many aspects of animal physiology and behaviour. They are highly regulated, among other mechanisms, by post-translational modifications of the transcription factors involved in their synthesis and response. In the present review, we will focus on the influence of SUMO (small ubiquitin-related modifier) and ubiquitin modifications on the function of transcription factors involved in adrenal cortex formation, steroidogenesis and the hormonal response.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adrenal Cortex / anatomy & histology
  • Adrenal Cortex / physiology
  • Animals
  • Humans
  • Protein Processing, Post-Translational*
  • Receptors, Cytoplasmic and Nuclear / metabolism
  • Receptors, Steroid / metabolism
  • Signal Transduction / physiology
  • Small Ubiquitin-Related Modifier Proteins / metabolism*
  • Steroids / metabolism*
  • Transcription Factors / metabolism
  • Ubiquitin / metabolism*

Substances

  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Steroid
  • Small Ubiquitin-Related Modifier Proteins
  • Steroids
  • Transcription Factors
  • Ubiquitin