Abstract
Deubiquitinases (DUBs) are emerging as important regulators of many pathways germane to cancer. They may regulate the stability of key oncogenes, exemplified by USP28 stabilisation of c-Myc. Alternatively they can negatively regulate ubiquitin-dependent signalling cascades such as the NF-kappaB activation pathway. We review the current literature that associates DUBs with cancer and discuss their suitability as drug targets of the future.
(c) 2010 IUBMB IUBMB Life.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Carboxypeptidases / physiology
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Carcinoma, Adenoid Cystic / physiopathology
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Cell Proliferation / drug effects
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Deubiquitinating Enzyme CYLD
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Endopeptidases / physiology*
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Fanconi Anemia / physiopathology
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Fatty Acid Synthases / physiology
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Forkhead Transcription Factors / physiology
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Genes, myc / physiology
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Humans
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Male
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NF-kappa B / physiology
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Neoplasms / metabolism
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Neoplasms / physiopathology*
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Oncogenes / physiology*
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PTEN Phosphohydrolase / physiology
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Peptide Hydrolases
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Prostatic Neoplasms / physiopathology
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Receptor Protein-Tyrosine Kinases / physiology
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Signal Transduction / physiology*
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Transforming Growth Factor beta / physiology
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Tumor Suppressor Protein p53 / physiology
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Tumor Suppressor Proteins / physiology
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Ubiquitin / metabolism*
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Ubiquitin Thiolesterase / physiology*
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Ubiquitin-Protein Ligases / physiology*
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Ubiquitin-Specific Peptidase 7
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Ubiquitin-Specific Proteases
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Wnt Proteins
Substances
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Forkhead Transcription Factors
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NF-kappa B
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Transforming Growth Factor beta
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Tumor Suppressor Protein p53
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Tumor Suppressor Proteins
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UCHL1 protein, human
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USP28 protein, human
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USP4 protein, human
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USP9X protein, human
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Ubiquitin
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Wnt Proteins
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Fatty Acid Synthases
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Ubiquitin-Protein Ligases
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Receptor Protein-Tyrosine Kinases
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PTEN Phosphohydrolase
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Carboxypeptidases
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Endopeptidases
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Peptide Hydrolases
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STAMBPL1 protein, human
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CYLD protein, human
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Deubiquitinating Enzyme CYLD
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UCHL5 protein, human
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USP2 protein, human
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USP7 protein, human
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Ubiquitin Thiolesterase
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Ubiquitin-Specific Peptidase 7
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Ubiquitin-Specific Proteases