Emerging roles of deubiquitinases in cancer-associated pathways

IUBMB Life. 2010 Feb;62(2):140-57. doi: 10.1002/iub.300.

Abstract

Deubiquitinases (DUBs) are emerging as important regulators of many pathways germane to cancer. They may regulate the stability of key oncogenes, exemplified by USP28 stabilisation of c-Myc. Alternatively they can negatively regulate ubiquitin-dependent signalling cascades such as the NF-kappaB activation pathway. We review the current literature that associates DUBs with cancer and discuss their suitability as drug targets of the future.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carboxypeptidases / physiology
  • Carcinoma, Adenoid Cystic / physiopathology
  • Cell Proliferation / drug effects
  • Deubiquitinating Enzyme CYLD
  • Endopeptidases / physiology*
  • Fanconi Anemia / physiopathology
  • Fatty Acid Synthases / physiology
  • Forkhead Transcription Factors / physiology
  • Genes, myc / physiology
  • Humans
  • Male
  • NF-kappa B / physiology
  • Neoplasms / metabolism
  • Neoplasms / physiopathology*
  • Oncogenes / physiology*
  • PTEN Phosphohydrolase / physiology
  • Peptide Hydrolases
  • Prostatic Neoplasms / physiopathology
  • Receptor Protein-Tyrosine Kinases / physiology
  • Signal Transduction / physiology*
  • Transforming Growth Factor beta / physiology
  • Tumor Suppressor Protein p53 / physiology
  • Tumor Suppressor Proteins / physiology
  • Ubiquitin / metabolism*
  • Ubiquitin Thiolesterase / physiology*
  • Ubiquitin-Protein Ligases / physiology*
  • Ubiquitin-Specific Peptidase 7
  • Ubiquitin-Specific Proteases
  • Wnt Proteins

Substances

  • Forkhead Transcription Factors
  • NF-kappa B
  • Transforming Growth Factor beta
  • Tumor Suppressor Protein p53
  • Tumor Suppressor Proteins
  • UCHL1 protein, human
  • USP28 protein, human
  • USP4 protein, human
  • USP9X protein, human
  • Ubiquitin
  • Wnt Proteins
  • Fatty Acid Synthases
  • Ubiquitin-Protein Ligases
  • Receptor Protein-Tyrosine Kinases
  • PTEN Phosphohydrolase
  • Carboxypeptidases
  • Endopeptidases
  • Peptide Hydrolases
  • STAMBPL1 protein, human
  • CYLD protein, human
  • Deubiquitinating Enzyme CYLD
  • UCHL5 protein, human
  • USP2 protein, human
  • USP7 protein, human
  • Ubiquitin Thiolesterase
  • Ubiquitin-Specific Peptidase 7
  • Ubiquitin-Specific Proteases