Abstract
Chloropupukeanolides A (1) and B (2), unprecedented spiroketal peroxides, and chloropupukeanone A (3), three highly functionalized metabolites featuring a chlorinated pupukeanane core, were isolated from an endophytic fungus Pestalotiopsis fici, with 1 showing significant anti-HIV-1 and cytotoxic effects.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / isolation & purification*
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Anti-HIV Agents / pharmacology*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Furans / chemistry
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Furans / isolation & purification
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Furans / pharmacology
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HIV-1 / drug effects
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Heterocyclic Compounds, 2-Ring / chemistry
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Heterocyclic Compounds, 2-Ring / isolation & purification
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Heterocyclic Compounds, 2-Ring / pharmacology
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Humans
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Models, Molecular
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Molecular Structure
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Peroxides / chemistry
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Peroxides / isolation & purification
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Peroxides / pharmacology
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Sesquiterpenes
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Spiro Compounds / chemistry
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Spiro Compounds / isolation & purification
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Spiro Compounds / pharmacology
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Xylariales / chemistry*
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Xylariales / metabolism
Substances
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Anti-HIV Agents
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Antineoplastic Agents
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Furans
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Heterocyclic Compounds, 2-Ring
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Peroxides
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Sesquiterpenes
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Spiro Compounds
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chloropupukeanolide
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chloropupukeanone
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spiroketal