Spatially mineralized self-assembled polymeric nanocarriers with enhanced robustness and controlled drug-releasing property

Hong Jae Lee; Sung Eun Kim; Il Keun Kwon; Chiyoung Park; Chulhee Kim; Jaemoon Yang; Sang Cheon Lee

doi:10.1039/b913732g

Spatially mineralized self-assembled polymeric nanocarriers with enhanced robustness and controlled drug-releasing property

Chem Commun (Camb). 2010 Jan 21;46(3):377-9. doi: 10.1039/b913732g. Epub 2009 Sep 18.

Authors

Hong Jae Lee¹, Sung Eun Kim, Il Keun Kwon, Chiyoung Park, Chulhee Kim, Jaemoon Yang, Sang Cheon Lee

Affiliation

¹ Department of Oral Biology & Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul 130-701, Korea.

PMID: 20066297
DOI: 10.1039/b913732g

Abstract

Polymer micelles with bioabsorbable mineralized calcium phosphate nanoshells have been synthesized and demonstrated to be robust nanocarriers for efficient intracellular drug delivery.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibiotics, Antineoplastic / administration & dosage*
Breast Neoplasms / drug therapy
Calcium Phosphates / chemical synthesis
Calcium Phosphates / chemistry*
Cell Line, Tumor
Delayed-Action Preparations / chemical synthesis
Delayed-Action Preparations / chemistry*
Doxorubicin / administration & dosage*
Female
Humans
Micelles*
Nanoshells / chemistry*
Nanoshells / ultrastructure
Polymers / chemical synthesis
Polymers / chemistry

Substances

Antibiotics, Antineoplastic
Calcium Phosphates
Delayed-Action Preparations
Micelles
Polymers
Doxorubicin
calcium phosphate