Abstract
Coresistance to human reserve antibiotics can be selected by antibiotics used in veterinary medicine. A Clostridium perfringens strain isolated from pig manure was resistant to the reserve drug linezolid and, simultaneously, resistant against florfenicol and erythromycin. We detected a new mutation in a highly conserved region of rplD, encoding protein L4 of the 50S ribosomal subunit. This is the first genetic substantiation of linezolid resistance in the genus Clostridium.
MeSH terms
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Acetamides / pharmacology*
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Animals
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Anti-Bacterial Agents / pharmacology
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Anti-Infective Agents / pharmacology*
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Clostridium perfringens / drug effects*
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Clostridium perfringens / genetics
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Clostridium perfringens / isolation & purification
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Drug Resistance, Bacterial / genetics*
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Erythromycin / pharmacology
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Humans
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Linezolid
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Manure / microbiology
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Microbial Sensitivity Tests
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Mutation*
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Oxazolidinones / pharmacology*
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Ribosomal Proteins / genetics*
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Swine
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Thiamphenicol / analogs & derivatives
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Thiamphenicol / pharmacology
Substances
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Acetamides
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Anti-Bacterial Agents
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Anti-Infective Agents
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Manure
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Oxazolidinones
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Ribosomal Proteins
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ribosomal protein L4
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Erythromycin
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florfenicol
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Thiamphenicol
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Linezolid