Boosting the brain's ability to block inflammation via microRNA-132

Immunity. 2009 Dec 18;31(6):854-5. doi: 10.1016/j.immuni.2009.11.004.

Abstract

The brain-immune axis continues to fascinate. In this issue of Immunity, Shaked et al. (2009) describe how miR-132 mediates an anti-inflammatory effect via the targeting of acetylcholinesterase, leading to an increase in the neurotransmitter acetylcholine.

MeSH terms

  • Acetylcholine / immunology
  • Acetylcholine / metabolism
  • Acetylcholinesterase / immunology*
  • Acetylcholinesterase / metabolism
  • Animals
  • Brain / drug effects
  • Brain / immunology*
  • Brain / metabolism
  • Cytokines / immunology*
  • Cytokines / metabolism
  • Inflammation / immunology*
  • Inflammation / metabolism
  • Lipopolysaccharides / immunology
  • Mice
  • MicroRNAs / agonists
  • MicroRNAs / immunology*
  • MicroRNAs / metabolism

Substances

  • Cytokines
  • Lipopolysaccharides
  • MIRN132 microRNA, mouse
  • MicroRNAs
  • Acetylcholinesterase
  • Acetylcholine