TLR2 looks at lipoproteins

Immunity. 2009 Dec 18;31(6):847-9. doi: 10.1016/j.immuni.2009.11.008.

Abstract

Toll-like receptors (TLRs) have evolved to recognize lipoproteins from diverse species of bacteria. In this issue of Immunity, Kang et al. (2009) provide insight into the mechanisms by which TLR2-TLR6 heterodimers recognize diacylated liporoteins, whereas TLR2-TLR1 heterodimers recognize triacylated lipopeptides.

Publication types

  • Comment

MeSH terms

  • Acylation
  • Acyltransferases / immunology
  • Acyltransferases / metabolism
  • Animals
  • Bacteria / immunology
  • Bacterial Outer Membrane Proteins / chemistry
  • Bacterial Outer Membrane Proteins / immunology
  • Humans
  • Immunity, Innate
  • Lipoproteins / chemistry
  • Lipoproteins / immunology*
  • Toll-Like Receptor 1 / immunology*
  • Toll-Like Receptor 2 / immunology*
  • Toll-Like Receptor 6 / immunology*

Substances

  • Bacterial Outer Membrane Proteins
  • Lipoproteins
  • Toll-Like Receptor 1
  • Toll-Like Receptor 2
  • Toll-Like Receptor 6
  • Acyltransferases