Abstract
Synthesis of a novel unnatural amino acid (2-FMPT) for the solid-phase synthesis of peptide-based probes suitable for target-specific activity-based profiling of protein tyrosine phosphatases from crude proteomes is reported.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Line
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Humans
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Molecular Structure
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Peptides / chemistry*
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Peptides / metabolism*
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Phosphotyrosine / analogs & derivatives*
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Protein Tyrosine Phosphatases / metabolism*
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Proteome / metabolism
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Proteomics*
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Substrate Specificity
Substances
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Peptides
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Proteome
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Phosphotyrosine
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Protein Tyrosine Phosphatases