Peptide-based activity-based probes (ABPs) for target-specific profiling of protein tyrosine phosphatases (PTPs)

Chem Commun (Camb). 2010 Jan 28;46(4):589-91. doi: 10.1039/b919744c. Epub 2009 Nov 17.

Abstract

Synthesis of a novel unnatural amino acid (2-FMPT) for the solid-phase synthesis of peptide-based probes suitable for target-specific activity-based profiling of protein tyrosine phosphatases from crude proteomes is reported.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Humans
  • Molecular Structure
  • Peptides / chemistry*
  • Peptides / metabolism*
  • Phosphotyrosine / analogs & derivatives*
  • Protein Tyrosine Phosphatases / metabolism*
  • Proteome / metabolism
  • Proteomics*
  • Substrate Specificity

Substances

  • Peptides
  • Proteome
  • Phosphotyrosine
  • Protein Tyrosine Phosphatases