Introduction: Cytomegalovirus generally causes self-limited, mild and asymptomatic infections in immunocompetent patients. An aggressive course in immunocompetent healthy patients is unusual.
Case presentation: We report the case of an immunocompetent 16-year-old Egyptian boy with encephalitis, acute renal failure, and acute hepatitis triggered by viral infection with a complete recovery following antiviral treatment.
Conclusion: We believe that this case adds to the understanding of the molecular biology, clinical presentation and increasing index of suspicion of many viral infections.