Experimental approaches to the study of epigenomic dysregulation in ageing

Exp Gerontol. 2010 Apr;45(4):255-68. doi: 10.1016/j.exger.2009.12.013. Epub 2010 Jan 10.

Abstract

In this review, we describe how normal ageing may involve the acquisition of epigenetic errors over time, akin to the accumulation of genetic mutations with ageing. We describe how such experiments are currently performed, their limitations technically and analytically and their application to ageing research.

Publication types

  • Review

MeSH terms

  • Aging / genetics*
  • Aging / physiology
  • Amino Acid Sequence
  • Animals
  • DNA Methylation / genetics
  • DNA Methylation / physiology
  • Epigenesis, Genetic / genetics*
  • Epigenesis, Genetic / physiology
  • Histones / genetics
  • Histones / physiology
  • Humans
  • Molecular Sequence Data
  • Mutation / genetics*

Substances

  • Histones