Regulation of enzyme activity through interactions with nanoparticles

Zhaochun Wu; Bin Zhang; Bing Yan

doi:10.3390/ijms10104198

Regulation of enzyme activity through interactions with nanoparticles

Int J Mol Sci. 2009 Nov 20;10(10):4198-4209. doi: 10.3390/ijms10104198.

Authors

Zhaochun Wu¹, Bin Zhang², Bing Yan^{2

3}

Affiliations

¹ School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
² School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
³ St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Abstract

The structure and function of an enzyme can be altered by nanoparticles (NPs). The interaction between enzyme and NPs is governed by the key properties of NPs, such as structure, size, surface chemistry, charge and surface shape. Recent representative studies on the NP-enzyme interactions and the regulation of enzyme activity by NPs with different size, composition and surface modification are reviewed.

Keywords: enzyme activity; nanoparticle; regulation.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Carbonic Anhydrases / chemistry
Carbonic Anhydrases / metabolism
Chymotrypsin / antagonists & inhibitors
Chymotrypsin / metabolism
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / metabolism
Enzymes / metabolism*
Humans
Nanoparticles / chemistry*
Nanoparticles / metabolism
Particle Size
Protein Binding

Substances

Enzyme Inhibitors
Enzymes
Chymotrypsin
Carbonic Anhydrases