Abstract
Titanocene difluorides can be obtained by halide metathesis of the respective titanocene dichlorides with trimethyltin fluoride (Me(3)SnF), giving access to a new class of cytotoxic active substances. Furthermore, an improved method for the synthesis of diaryl-substituted titanocene dichlorides is presented.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Combined Chemotherapy Protocols
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Apoptosis / drug effects
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Cell Line, Tumor
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Cell Proliferation / drug effects*
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Drug Resistance, Neoplasm / drug effects
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Drug Resistance, Neoplasm / genetics
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Drug Screening Assays, Antitumor
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Drug Synergism
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Inhibitory Concentration 50
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Kidney Neoplasms / drug therapy
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LLC-PK1 Cells
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Male
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Mice
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Mice, Nude
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Molecular Structure
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Neoplasm Transplantation
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Organometallic Compounds / chemical synthesis*
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Organometallic Compounds / pharmacology*
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Prostatic Neoplasms / pathology
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Proto-Oncogene Proteins c-bcl-2
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Structure-Activity Relationship
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Swine
Substances
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Organometallic Compounds
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Proto-Oncogene Proteins c-bcl-2
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titanocene
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titanocene dichloride