Titanocene difluorides with improved cytotoxic activity

Inorg Chem. 2010 Feb 15;49(4):1292-4. doi: 10.1021/ic9022163.

Abstract

Titanocene difluorides can be obtained by halide metathesis of the respective titanocene dichlorides with trimethyltin fluoride (Me(3)SnF), giving access to a new class of cytotoxic active substances. Furthermore, an improved method for the synthesis of diaryl-substituted titanocene dichlorides is presented.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Combined Chemotherapy Protocols
  • Apoptosis / drug effects
  • Cell Line, Tumor
  • Cell Proliferation / drug effects*
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Drug Resistance, Neoplasm / drug effects
  • Drug Resistance, Neoplasm / genetics
  • Drug Screening Assays, Antitumor
  • Drug Synergism
  • Inhibitory Concentration 50
  • Kidney Neoplasms / drug therapy
  • LLC-PK1 Cells
  • Male
  • Mice
  • Mice, Nude
  • Molecular Structure
  • Neoplasm Transplantation
  • Organometallic Compounds / chemical synthesis*
  • Organometallic Compounds / pharmacology*
  • Prostatic Neoplasms / pathology
  • Proto-Oncogene Proteins c-bcl-2
  • Structure-Activity Relationship
  • Swine

Substances

  • Organometallic Compounds
  • Proto-Oncogene Proteins c-bcl-2
  • titanocene
  • titanocene dichloride