Selenium (Se) supplementation may prevent the formation of free radicals and lipid peroxidation processes in trichinellosis. The oxidative-antioxidant status of male Wistar rats infected or uninfected with Trichinella spiralis (Nematoda) and supplemented or unsupplemented with Sel-plex (Alltech) was tested through blood biomarkers. Sel-plex was applied to restore antioxidant defense system. The oxidative marker was malondialdehyde (MDA) concentration. The antioxidant markers were superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and concentrations of Se and vitamin E. The animals were allocated into four groups. The experiment covered 8 weeks post infection. A mathematical model was proposed for the time course of host body weight. The model solutions were in good agreement with the experimental data. The relative rates of body weight gain were determined as growth kinetic parameters. The supplementation of the rats with dietary Se improved their antioxidant status. Increases by 10% in SOD activity, 6% in GPx activity, 13% in vitamin E concentration, 17% in plasma Se concentration, and 19% in liver Se concentration, respectively, and a decrease by 18% in serum MDA concentration were recorded in the infected and supplemented towards infected and unsupplemented rats. The reduction of muscle larvae after Sel-plex application was 63%. The mortality in infected and uninfected animals did not differ significantly. No statistically significant differences were established between the growth of the control and infected rats. At week 8, the body weight gain in the supplemented rats (both uninfected and infected) was 30% higher, compared to that in unsupplemented ones. Diet with Se could be beneficial in the treatment of diseases correlated with considerable oxidative stress, particularly parasitoses.