One of the many potential sequelae of intensive care is prolonged weakness, which can be associated with increased morbidity during the intensive care unit stay and long-term functional disability. Despite increased awareness of this complication in recent years, diagnosing intensive care unit-acquired weakness remains difficult and there are no specific therapies. Management, therefore, relies on limiting its short- and long-term effects. One method by which this may be achieved is to reduce sedative use and promote early mobilization and exercise.