Four new ent-kauranoids from Isodon rubescens var. lushanensis and data reassignment of dayecrystal B

Chem Pharm Bull (Tokyo). 2010 Jan;58(1):56-60. doi: 10.1248/cpb.58.56.

Abstract

Four new 7, 20-epoxy-ent-kauranoids, rubluanins A-D (1-4) and eleven known ones, were isolated from Isodon rubescens var. lushanensis, and their structures were elucidated by spectroscopic analysis. Compounds 2-14 were evaluated for their cytotoxicity in several human tumor cell lines (U937, Jurkat, HL-60, K562, SGC790, and HepG2). Among the compounds, lasiokaurin (13) showed significant cytotoxic activity of 0.62 microM (IC(50)) in U937 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / analysis*
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacokinetics*
  • Cell Survival / drug effects
  • Diterpenes / analysis
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology
  • Diterpenes, Kaurane / analysis*
  • Diterpenes, Kaurane / isolation & purification
  • Diterpenes, Kaurane / pharmacology*
  • Drug Screening Assays, Antitumor
  • Humans
  • Isodon / chemistry*
  • Models, Molecular
  • Molecular Structure
  • Neoplasms / drug therapy

Substances

  • Antineoplastic Agents, Phytogenic
  • Diterpenes
  • Diterpenes, Kaurane
  • lasiokaurin