Analysis of whole-arm translocations in malignant blood cells by nonisotopic in situ hybridization

Cytogenet Cell Genet. 1991;56(1):14-7. doi: 10.1159/000133036.

Abstract

Whole-arm translocations in five leukemic patients were studied using nonisotopic in situ hybridization with alpha satellite DNA and simple satellite chromosome-specific DNA probes to detect the target sequences. The results show that this technique provides additional information on the involvement of these DNA sequences in whole-arm translocations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Centromere
  • Child
  • DNA Probes
  • DNA, Neoplasm / analysis
  • DNA, Neoplasm / genetics*
  • DNA, Satellite
  • Female
  • Humans
  • Karyotyping
  • Leukemia / blood
  • Leukemia / genetics*
  • Male
  • Middle Aged
  • Nucleic Acid Hybridization
  • Translocation, Genetic*

Substances

  • DNA Probes
  • DNA, Neoplasm
  • DNA, Satellite