Reproductive health effects of aflatoxins: a review of the literature

Reprod Toxicol. 2010 Jun;29(3):262-70. doi: 10.1016/j.reprotox.2009.12.005. Epub 2010 Jan 5.

Abstract

Context: Although it is known that aflatoxins have many adverse health effects, there is no systematic summary of how it affects the reproductive system or its reproductive health effects.

Objective: Summarize evidence on the reproductive health effects of aflatoxins.

Results: The search yielded 121 potential studies, of which 25 were retained. One study found a higher concentration of aflatoxins in the semen of infertile men (40% of cases compared to 8% of controls). Six studies found significant associations or correlations between low birth weight and aflatoxins while one study did not find any correlation. One study found maternal serum aflatoxin to be a risk factor for jaundice in infants (OR, 2.68; CI, 1.18-6.10). Overall, maternal breast milk in developing countries had higher rates of aflatoxin contamination than in high income countries.

Conclusions: Stakeholders in developing countries need to take steps to reduce exposure of vulnerable populations to the toxic effects of aflatoxins.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Aflatoxins / toxicity*
  • Developing Countries
  • Female
  • Humans
  • Infant
  • Infant, Low Birth Weight
  • Infant, Newborn
  • Male
  • Milk, Human
  • Pregnancy
  • Reproductive Medicine*
  • Risk Factors

Substances

  • Aflatoxins