The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii

Robert W Huigens 3rd; Samuel Reyes; Catherine S Reed; Cynthia Bunders; Steven A Rogers; Andrew T Steinhauer; Christian Melander

doi:10.1016/j.bmc.2009.12.003

The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii

Bioorg Med Chem. 2010 Jan 15;18(2):663-74. doi: 10.1016/j.bmc.2009.12.003. Epub 2009 Dec 6.

Authors

Robert W Huigens 3rd¹, Samuel Reyes, Catherine S Reed, Cynthia Bunders, Steven A Rogers, Andrew T Steinhauer, Christian Melander

Affiliation

¹ North Carolina State University Chemistry Department, 2620 Yarborough Drive, Raleigh, NC 27695-8204, USA.

PMID: 20044260
DOI: 10.1016/j.bmc.2009.12.003

Abstract

Multidrug-resistant bacterial infections continue to be a rising global health concern. Herein is described the development of a class of novel 2-aminobenzimidazoles with antibiotic activity. These active 2-aminobenzimidazoles retain their antibiotic activity against several strains of multidrug-resistant Staphylococcus aureus and Acinetobacter baumannii when compared to susceptible strains.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acinetobacter baumannii / drug effects*
Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Benzimidazoles / chemical synthesis*
Benzimidazoles / chemistry
Benzimidazoles / pharmacology*
Drug Resistance, Multiple, Bacterial*
Methicillin-Resistant Staphylococcus aureus / drug effects*
Microbial Sensitivity Tests
Molecular Conformation
Small Molecule Libraries
Stereoisomerism
Structure-Activity Relationship

Substances

Anti-Bacterial Agents
Benzimidazoles
Small Molecule Libraries
2-aminobenzimidazole