Abstract
B cells are of increasing importance as a target for multiple sclerosis treatment. Here we show that GA treatment of mice with experimental autoimmune encephalomyelitis (EAE) biases cytokine production by B cells towards cytokines associated with regulation in MS including interleukin (IL)-4, -10 and -13 and reduces pro-inflammatory IL-6, IL-12, and TNF alpha levels. GA also down-regulates expression of B cell-activating factor (BAFF) of the TNF family and a proliferation-inducing ligand (APRIL), as well as the BAFF receptor in mice with EAE. Thus, GA impacts both B cell survival and B cell cytokine production during CNS inflammatory disease in an EAE model.
Copyright 2009 Elsevier B.V. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigens, CD19 / metabolism
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B-Cell Activating Factor / genetics
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B-Cell Activating Factor / metabolism
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B-Lymphocytes / drug effects
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Brain / pathology
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CD5 Antigens / metabolism
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Cells, Cultured
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Cytokines / genetics
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Cytokines / metabolism*
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Disease Models, Animal
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Encephalomyelitis, Autoimmune, Experimental / chemically induced
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Encephalomyelitis, Autoimmune, Experimental / drug therapy*
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Encephalomyelitis, Autoimmune, Experimental / pathology
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Female
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Flow Cytometry / methods
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Gene Expression Regulation / drug effects*
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Glatiramer Acetate
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Glycoproteins
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Immunosuppressive Agents / pharmacology
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Immunosuppressive Agents / therapeutic use*
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Lymph Nodes / pathology
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Mice
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Mice, Inbred C57BL
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Myelin-Oligodendrocyte Glycoprotein
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Peptide Fragments
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Peptides / pharmacology
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Peptides / therapeutic use*
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RNA, Messenger / metabolism
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Spleen / pathology
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Tumor Necrosis Factor Ligand Superfamily Member 13 / genetics
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Tumor Necrosis Factor Ligand Superfamily Member 13 / metabolism
Substances
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Antigens, CD19
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B-Cell Activating Factor
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CD5 Antigens
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Cytokines
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Glycoproteins
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Immunosuppressive Agents
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Myelin-Oligodendrocyte Glycoprotein
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Peptide Fragments
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Peptides
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RNA, Messenger
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Tnfsf13b protein, mouse
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Tumor Necrosis Factor Ligand Superfamily Member 13
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myelin oligodendrocyte glycoprotein (35-55)
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Glatiramer Acetate