Objectives: Parkinson's disease is a complex disease with multiple etiological factors involved in disease pathogenesis, and the molecular and cellular pathways for neurodegeneration are still elusive.
Methods: We reviewed all the relevant laboratory findings regarding acupuncture mechanism on Parkinson's disease.
Results: Acupuncture treatments in animal experiments have generated valuable mechanistic insights of Parkinson's disease and shown that acupuncture therapy is in fact a neuroprotective therapy which increases various neuroprotective agents such as brain-derived neurotrophic factor, glial cell line-derived neurotrophic factor and cyclophilin A. In addition, acupuncture therapy decreases cell death processes and attenuates oxidative stress to substantia nigra dopaminergic neurons.
Discussion: These results suggest that early application of acupuncture therapy for Parkinson's disease patients may be helpful for the best efficacy of acupuncture treatment.