NASA's Chandra X-ray Observatory and the ESA's X-ray Multi-Mirror Mission (XMM-Newton) made their first observations ten years ago. The complementary capabilities of these observatories allow us to make high-resolution images and precisely measure the energy of cosmic X-rays. Less than 50 years after the first detection of an extrasolar X-ray source, these observatories have achieved an increase in sensitivity comparable to going from naked-eye observations to the most powerful optical telescopes over the past 400 years. We highlight some of the many discoveries made by Chandra and XMM-Newton that have transformed twenty-first century astronomy.