Synthesis and antitumor activities of phenanthrene-based alkaloids

Songtao Li; Li Han; Liang Sun; Dan Zheng; Jiang Liu; Yingbo Fu; Xueshi Huang; Zhanyou Wang

doi:10.3390/molecules14125042

Synthesis and antitumor activities of phenanthrene-based alkaloids

Molecules. 2009 Dec 7;14(12):5042-53. doi: 10.3390/molecules14125042.

Authors

Songtao Li¹, Li Han, Liang Sun, Dan Zheng, Jiang Liu, Yingbo Fu, Xueshi Huang, Zhanyou Wang

Affiliation

¹ Department of Natural Products Chemistry, Pharmaceutical School, China Medical University, Shenyang 110001, China.

Abstract

A series of phenanthrene-based tylophorine derivatives (PBTs) were synthesized and their cytotoxic activities against the H460 human large-cell lung carcinoma cell line were evaluated. Among these compounds, N-(3-hydroxy-2,6,7-tri-methoxyphenanthr-9-ylmethyl)-L-prolinol (5a), and N-(3-hydroxy-2,6,7-trimethoxy-phenanthr-9-ylmethyl)-L-valinol (9) exhibited good activities, with IC(50) values of 11.6 and 6.1 microM, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemical synthesis*
Alkaloids / chemistry
Alkaloids / pharmacology*
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Drug Screening Assays, Antitumor
Magnetic Resonance Spectroscopy
Phenanthrenes / chemistry*
Spectrometry, Mass, Electrospray Ionization

Substances

Alkaloids
Antineoplastic Agents
Phenanthrenes
phenanthrene