Abstract
In this work, a number of lipidic amino alcohols wereas synthesized and evaluated in vitro on cultures of Leishmania amazonensis and Leishmania chagasi. Nine amino alcohols showed inhibition of L. chagasi growth, and seven of them showed inhibition of L. amazonensis with IC(50) below 10 microm. Compound 11f was more active than the reference drug amphotericin B against L. chagasi promastigote forms.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amino Alcohols / chemical synthesis*
-
Amino Alcohols / chemistry
-
Amino Alcohols / pharmacology
-
Amphotericin B / pharmacology
-
Humans
-
Leishmania / drug effects*
-
Leishmania / growth & development
-
Trypanocidal Agents / chemical synthesis*
-
Trypanocidal Agents / chemistry
-
Trypanocidal Agents / pharmacology
Substances
-
Amino Alcohols
-
Trypanocidal Agents
-
Amphotericin B