Ortho-C-H borylation of benzoate esters with bis(pinacolato)diboron catalyzed by iridium-phosphine complexes

Tatsuo Ishiyama; Hironori Isou; Takao Kikuchi; Norio Miyaura

doi:10.1039/b910298a

Ortho-C-H borylation of benzoate esters with bis(pinacolato)diboron catalyzed by iridium-phosphine complexes

Chem Commun (Camb). 2010 Jan 7;46(1):159-61. doi: 10.1039/b910298a. Epub 2009 Nov 17.

Authors

Tatsuo Ishiyama¹, Hironori Isou, Takao Kikuchi, Norio Miyaura

Affiliation

¹ Division of Chemical Process Engineering, Graduate School of Engineering, Hokkaido University, Sapporo 060-8628, Japan. ishiyama@eng.hokudai.ac.jp

PMID: 20024326
DOI: 10.1039/b910298a

Abstract

Iridium complexes generated from [Ir(OMe)(COD)](2) and tris[3,5-bis(trifluoromethyl)phenyl]phosphine efficiently catalyzed the ortho-C-H borylation of benzoate esters with bis(pinacolato)diboron in octane at 80 degrees C to produce the corresponding arylboronates in high yields with excellent regioselectivities.