Abstract
An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5-[(18)F]fluororibose, a novel [(18)F]-fluorinated sugar suitable for positron emission tomography (PET) applications.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Proteins / metabolism*
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Biocatalysis
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Cell Line, Tumor
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Fluorine Radioisotopes / chemistry
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Halogenation
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Humans
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N-Glycosyl Hydrolases / metabolism*
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Oxidoreductases / metabolism*
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Positron-Emission Tomography*
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Ribose / analogs & derivatives*
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Ribose / chemical synthesis
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Ribose / chemistry
Substances
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5-deoxy-5-(18F)fluororibose
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Bacterial Proteins
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Fluorine Radioisotopes
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Ribose
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Oxidoreductases
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fluorinase
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N-Glycosyl Hydrolases