An enzymatic route to 5-deoxy-5-[18F]fluoro-D-ribose, a [18F]-fluorinated sugar for PET imaging

Chem Commun (Camb). 2010 Jan 7;46(1):139-41. doi: 10.1039/b919364b. Epub 2009 Nov 10.

Abstract

An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5-[(18)F]fluororibose, a novel [(18)F]-fluorinated sugar suitable for positron emission tomography (PET) applications.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins / metabolism*
  • Biocatalysis
  • Cell Line, Tumor
  • Fluorine Radioisotopes / chemistry
  • Halogenation
  • Humans
  • N-Glycosyl Hydrolases / metabolism*
  • Oxidoreductases / metabolism*
  • Positron-Emission Tomography*
  • Ribose / analogs & derivatives*
  • Ribose / chemical synthesis
  • Ribose / chemistry

Substances

  • 5-deoxy-5-(18F)fluororibose
  • Bacterial Proteins
  • Fluorine Radioisotopes
  • Ribose
  • Oxidoreductases
  • fluorinase
  • N-Glycosyl Hydrolases