Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents

Wen-Shan Li; Shivaji V More; Chie-Hong Wang; Ya Ching Jen; Ching-Fa Yao; Tein-Fu Wang; Chin-Chun Hung; Shu-Chuan Jao

doi:10.1016/j.bmcl.2009.12.017

Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents

Bioorg Med Chem Lett. 2010 Feb 1;20(3):1148-52. doi: 10.1016/j.bmcl.2009.12.017. Epub 2009 Dec 6.

Authors

Wen-Shan Li¹, Shivaji V More, Chie-Hong Wang, Ya Ching Jen, Ching-Fa Yao, Tein-Fu Wang, Chin-Chun Hung, Shu-Chuan Jao

Affiliation

¹ Institute of Chemistry, Academia Sinica, Taipei 115, Taiwan.

PMID: 20022505
DOI: 10.1016/j.bmcl.2009.12.017

Abstract

This study describes the synthesis and structure-activity relationships of a series of furazan-3,4-diamide analogs. 1,2,5-Oxadiazole ring and electron-withdrawing substituent on the phenyl ring are proposed to be the important elements which contribute to a significant extent maximal potency of anti-proliferation effect.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / therapeutic use
Cell Line, Tumor
Cell Proliferation / drug effects
Diamide / analogs & derivatives*
Diamide / chemical synthesis*
Diamide / therapeutic use
Furans / chemical synthesis*
Furans / therapeutic use
Humans
Structure-Activity Relationship

Substances

Antineoplastic Agents
Furans
Diamide