Mechanisms of mutual influence and aggravation of splanchnic organ and oral cavity diseases are discussed in the context of the integral anthropological approach. The systemic character of analysis of pathogenetic mechanisms of chronic generalized periodontitis dictates the necessity of an absolutely new conceptual outlook of organization and implementation of medical and preventive measures designed to activate sanogenetic responses and to enhance the regulatory potential and functional reserves of the organism in the presence of developing periodontitis. It was shown that inclusion of intermittent hypoxic training in the combined rehabilitative treatment of the patients with chronic periodontitis substantially promotes corrective influences on periodontal tissues and ensures stable clinical effect.