Abstract
The risk of transmission of porcine endogenous retrovirus (PERV) is one of the major safety issues in xenotransplantation. Human tetherin, recently described as an antiviral protein able to inhibit the release of enveloped viruses, and its porcine homologue were shown to inhibit PERV release from producer cells, establishing themselves as candidate molecules to suppress PERV production in porcine xenografts by animal engineering.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Animals, Genetically Modified
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Antigens, CD / genetics
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Antigens, CD / metabolism*
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Cell Line
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Endogenous Retroviruses / genetics
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Endogenous Retroviruses / metabolism*
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GPI-Linked Proteins
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Humans
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Membrane Glycoproteins / genetics
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Membrane Glycoproteins / metabolism*
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Molecular Sequence Data
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Protein Isoforms / genetics
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Protein Isoforms / metabolism*
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Sequence Alignment
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Swine Diseases* / transmission
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Swine Diseases* / virology
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Swine*
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Transplantation, Heterologous / adverse effects
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Zoonoses / virology
Substances
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Antigens, CD
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BST2 protein, human
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GPI-Linked Proteins
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Membrane Glycoproteins
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Protein Isoforms