Discovery of a new and efficient small molecule for neuronal differentiation from mesenchymal stem cell

Na Ri Kim; Seung Kyu Kang; Hyun Hee Ahn; Sung Wook Kwon; Woul Seong Park; Ki Suk Kim; Sung Soo Kim; Hee Jung Jung; Sang Un Choi; Jin Hee Ahn; Kwang Rok Kim

doi:10.1021/jm9015558

Discovery of a new and efficient small molecule for neuronal differentiation from mesenchymal stem cell

J Med Chem. 2009 Dec 24;52(24):7931-3. doi: 10.1021/jm9015558.

Authors

Na Ri Kim¹, Seung Kyu Kang, Hyun Hee Ahn, Sung Wook Kwon, Woul Seong Park, Ki Suk Kim, Sung Soo Kim, Hee Jung Jung, Sang Un Choi, Jin Hee Ahn, Kwang Rok Kim

Affiliation

¹ Korea Research Institute of Chemical Technology, Daejeon, 305-600, Korea.

PMID: 20014867
DOI: 10.1021/jm9015558

Abstract

A new synthetic small molecule, compound 1, which induced a neuronal differentiation from mesenchymal stem cells (MSCs) with an excellent efficiency, was identified. Furthermore the differentiated cell by 1 showed the neural electrophysiological and cholinergic neuron properties.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Differentiation / drug effects
Cell Differentiation / genetics
Cell Line
Electrophysiological Phenomena
Gene Expression Profiling
Mesenchymal Stem Cells / cytology
Mesenchymal Stem Cells / drug effects*
Mesenchymal Stem Cells / physiology
Neurons / cytology
Neurons / drug effects*
Neurons / physiology
Rats