Total solid-phase synthesis of NOTA-functionalized peptides for PET imaging

Org Lett. 2010 Jan 15;12(2):280-3. doi: 10.1021/ol902601x.

Abstract

A convenient approach to functionalize peptides either at the N-terminal or on a lysine side chain with 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA) chelating unit has been developed on solid support. The chelate was assembled in a two-step process starting with bromo-acetylated peptides. Deprotection and cleavage of the resin-bound NOTA peptides were performed with use of trifluoroacetic acid (TFA) in the presence of thioanisole and water to give free NOTA peptides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Heterocyclic Compounds / chemical synthesis*
  • Heterocyclic Compounds / chemistry
  • Heterocyclic Compounds, 1-Ring
  • Molecular Structure
  • Peptides / chemical synthesis*
  • Peptides / chemistry
  • Positron-Emission Tomography*

Substances

  • Heterocyclic Compounds
  • Heterocyclic Compounds, 1-Ring
  • Peptides
  • 1,4,7-triazacyclononane-N,N',N''-triacetic acid