The roles of tetraspanins in HIV-1 replication

Curr Top Microbiol Immunol. 2009:339:85-102. doi: 10.1007/978-3-642-02175-6_5.

Abstract

Tetraspanins are small integral membrane proteins that are known to control a variety of cellular processes, including signaling, migration and cell-cell fusion. Research over the past few years established that they are also regulators of various steps in the HIV-1 replication cycle, but the mechanisms through which these proteins either enhance or repress virus spread remain largely unknown.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, CD / physiology*
  • HIV-1 / physiology*
  • Host-Pathogen Interactions
  • Humans
  • Membrane Glycoproteins / physiology*
  • Platelet Membrane Glycoproteins / physiology*
  • Tetraspanin 28
  • Tetraspanin 29
  • Tetraspanin 30
  • Transcription, Genetic
  • Virus Internalization
  • Virus Replication*

Substances

  • Antigens, CD
  • CD63 protein, human
  • CD81 protein, human
  • CD9 protein, human
  • Membrane Glycoproteins
  • Platelet Membrane Glycoproteins
  • Tetraspanin 28
  • Tetraspanin 29
  • Tetraspanin 30