Checkpoint Mec-tivation comes in many flavors

Lee Zou

doi:10.1016/j.molcel.2009.11.026

Checkpoint Mec-tivation comes in many flavors

Mol Cell. 2009 Dec 11;36(5):734-5. doi: 10.1016/j.molcel.2009.11.026.

Author

Lee Zou¹

Affiliation

¹ Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA. zou.lee@mgh.harvard.edu

PMID: 20005837
DOI: 10.1016/j.molcel.2009.11.026

Abstract

In this issue of Molecular Cell, Navadgi-Patil and Burgers show that the budding yeast Mec1 kinase is activated by DNA damage through two distinct Ddc1-mediated mechanisms during G1 and G2 phases of the cell cycle.

Publication types

Comment

MeSH terms

Cell Cycle
Cell Cycle Proteins / physiology
DNA Damage
Enzyme Activation / physiology
Intracellular Signaling Peptides and Proteins / metabolism*
Protein Serine-Threonine Kinases / metabolism*
Saccharomyces cerevisiae / enzymology*
Saccharomyces cerevisiae Proteins / metabolism*
Saccharomyces cerevisiae Proteins / physiology

Substances

Cell Cycle Proteins
DPB11 protein, S cerevisiae
Ddc1 protein, S cerevisiae
Intracellular Signaling Peptides and Proteins
Saccharomyces cerevisiae Proteins
MEC1 protein, S cerevisiae
Protein Serine-Threonine Kinases