Crystal structure of bucain, a three-fingered toxin from the venom of the Malayan krait (Bungarus candidus)

Protein Pept Lett. 2009;16(12):1473-7. doi: 10.2174/092986609789839304.

Abstract

Bucain, a potent neurotoxin isolated from the venom of the Malayan krait (Bungarus candidus), induces paralysis and death. Its crystal structure has been determined at 2.10 A resolution and based on the molecular topology and hydrophobicity profile is structurally classified as a three-fingered alpha-neurotoxin possessing a positively charged AChR-binding site.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Binding Sites
  • Bungarotoxins / chemistry*
  • Bungarotoxins / isolation & purification
  • Bungarotoxins / metabolism
  • Bungarus / metabolism*
  • Crystallization
  • Crystallography, X-Ray
  • Elapid Venoms / chemistry
  • Elapid Venoms / isolation & purification
  • Elapid Venoms / metabolism
  • Molecular Sequence Data
  • Neurotoxins / chemistry*
  • Neurotoxins / isolation & purification
  • Neurotoxins / metabolism
  • Protein Structure, Secondary
  • Receptors, Cholinergic / metabolism
  • Sequence Alignment
  • Toxins, Biological / chemistry*
  • Toxins, Biological / isolation & purification
  • Toxins, Biological / metabolism

Substances

  • Bungarotoxins
  • Elapid Venoms
  • Neurotoxins
  • Receptors, Cholinergic
  • Toxins, Biological
  • bucain
  • bucandin