Abstract
Bucain, a potent neurotoxin isolated from the venom of the Malayan krait (Bungarus candidus), induces paralysis and death. Its crystal structure has been determined at 2.10 A resolution and based on the molecular topology and hydrophobicity profile is structurally classified as a three-fingered alpha-neurotoxin possessing a positively charged AChR-binding site.
MeSH terms
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Amino Acid Sequence
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Animals
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Binding Sites
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Bungarotoxins / chemistry*
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Bungarotoxins / isolation & purification
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Bungarotoxins / metabolism
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Bungarus / metabolism*
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Crystallization
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Crystallography, X-Ray
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Elapid Venoms / chemistry
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Elapid Venoms / isolation & purification
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Elapid Venoms / metabolism
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Molecular Sequence Data
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Neurotoxins / chemistry*
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Neurotoxins / isolation & purification
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Neurotoxins / metabolism
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Protein Structure, Secondary
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Receptors, Cholinergic / metabolism
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Sequence Alignment
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Toxins, Biological / chemistry*
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Toxins, Biological / isolation & purification
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Toxins, Biological / metabolism
Substances
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Bungarotoxins
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Elapid Venoms
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Neurotoxins
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Receptors, Cholinergic
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Toxins, Biological
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bucain
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bucandin