Eradication of Helicobacter pylori (H. pylori) has suggested not only the decrease in the incidence of peptic ulcer diseases and gastric cancer, and but also the improvement of dyspeptic symptoms. Dyspepsia is a common condition in the world, and dyspepsia-related medical cost is high due to consultations, investigations, and drug consumption. Although the role of H. pylori in functional dyspepsia is still unknown, recent studies including meta-analysis have indicated that H. pylori eradication improves dyspeptic symptoms. In addition, the reduction of medical cost by H. pylori eradication has been discussed in the more recent studies.