Aim: We studied morphologic modifications of the endometrium induced by leuprorelin acetate, a gonadotropin-releasing hormone agonist, in women with uterine myomata.
Methods: Transmission and scanning electron microscopy observations were performed after 2 or 6 cycles of therapy (every 28 days).
Results: A near-normal endometrium was observed after 2 months of therapy, while treatment with 6 cycles of leuprorelin acetate induced a uniform morphologic regression of the uterine mucosa.
Conclusions: The study demonstrates that leuprorelin acetate induces a unique and time-dependent regression of the endometrial mucous membrane.
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