Target Controlled Infusion algorithms for anesthesia: theory vs practical implementation

Nadja Bressan; A Paulo Moreira; Pedro Amorim; Catarina S Nunes

doi:10.1109/IEMBS.2009.5334653

Target Controlled Infusion algorithms for anesthesia: theory vs practical implementation

Annu Int Conf IEEE Eng Med Biol Soc. 2009:2009:6234-7. doi: 10.1109/IEMBS.2009.5334653.

Authors

Nadja Bressan¹, A Paulo Moreira, Pedro Amorim, Catarina S Nunes

Affiliation

¹ University of Porto, Faculty of Engineering, Department of Electrical and Computer Engineering, Portugal. nadja.bressan@fe.up.pt

PMID: 19965087
DOI: 10.1109/IEMBS.2009.5334653

Abstract

Target Controlled Infusion (TCI) systems are based in drug pharmacokinetic and pharmacodynamic models implemented in an algorithm to drive an infusion pump. Infusion control algorithms have been designed, implemented and validated for several anesthetic drugs, devices and controllers. The maintenance phase in these algorithms is represented by an equation that compensates the loss of drug from the central compartment and maintains the set target concentration. The goal of the current study was to improve existing TCI software with a new method for the maintenance phase. We compared and analyzed two different methods to find the more efficient method for the maintenance phase in an open-loop control TCI system.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Algorithms*
Anesthetics, General / administration & dosage*
Anesthetics, General / pharmacokinetics*
Computer Simulation
Drug Therapy, Computer-Assisted / methods*
Humans
Infusions, Intravenous
Models, Biological*
Reproducibility of Results
Sensitivity and Specificity

Substances

Anesthetics, General