A dual-wavelength fiber-optic pulse oximetry system was developed for the purposes of estimating oxygen saturation from the esophagus. A probe containing miniature right-angled glass prisms was used to record photoplethysmographic (PPG) signals from the esophageal wall. Signals were recorded successfully in 19 of 20 patients, demonstrating that PPG signals could be reliably obtained from an internal vascularized tissue site such as the esophageal epithelium. The value of the mean oxygen saturation recorded from the esophagus was 94.0 +/- 4.0%. These results demonstrate that SpO(2) may be estimated in the esophagus using a fiber-optic probe and this may be the first report of such measurements.