Modulation of arousal regulation with central thalamic deep brain stimulation

Sudhin A Shah; Jonathan L Baker; Jae-Wook Ryou; Keith P Purpura; Nicholas D Schiff

doi:10.1109/IEMBS.2009.5333751

Modulation of arousal regulation with central thalamic deep brain stimulation

Annu Int Conf IEEE Eng Med Biol Soc. 2009:2009:3314-7. doi: 10.1109/IEMBS.2009.5333751.

Authors

Sudhin A Shah¹, Jonathan L Baker, Jae-Wook Ryou, Keith P Purpura, Nicholas D Schiff

Affiliation

¹ Physiology, Biophysics and Systems Biology Department, Weill Cornell Graduate School of Biomedical Sciences, NY, NY 10021, USA. sut2006@med.cornell.edu

PMID: 19964301
DOI: 10.1109/IEMBS.2009.5333751

Abstract

To investigate the effects of central thalamic deep brain stimulation (CT/DBS) on behavior and frontal cortical function, we conducted experiments in an awake, behaving macaque monkey performing tasks that required sustained attention and working memory. Results of this preliminary study revealed that CT/DBS can lead to an improvement, a decrement, a mixed or have no effect on behavior.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Animals
Arousal
Attention
Behavior
Behavior, Animal
Brain / pathology*
Deep Brain Stimulation / methods*
Electrophysiology / methods
Humans
Macaca
Male
Memory, Short-Term
Neural Pathways
Neurons / pathology