Hypoxic-ischemic brain injury in neonatal piglets with different histological outcomes: An amplitude-integrated EEG study

Annu Int Conf IEEE Eng Med Biol Soc. 2009:2009:1127-30. doi: 10.1109/IEMBS.2009.5333439.

Abstract

To test the reliability of amplitude-integrated electroencephalogram (aEEG) in cerebral hypoxic ischemia (HI), 12 neonatal piglets subjected to different levels of HI are divided into three groups based on the histological outcomes obtained 4 days after experiment. Results show that concomitant with the increased severity of brain injury, the upper and lower margins of aEEG decrease significantly (p < 0.05) during early recovery period after HI (about 2 hours post-resuscitation). We conclude that aEEG method reliably reflects hypoxic-ischemic cerebral injury and constitutes a valuable monitoring tool in neonatal intensive care unit (NICU).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Asphyxia Neonatorum / diagnosis
  • Biomedical Engineering
  • Brain Injuries / diagnosis*
  • Brain Injuries / pathology
  • Brain Injuries / physiopathology
  • Disease Models, Animal
  • Electroencephalography / methods*
  • Electroencephalography / statistics & numerical data
  • Humans
  • Hypoxia-Ischemia, Brain / diagnosis*
  • Hypoxia-Ischemia, Brain / pathology
  • Hypoxia-Ischemia, Brain / physiopathology
  • Infant, Newborn
  • Male
  • Monitoring, Physiologic / methods
  • Monitoring, Physiologic / statistics & numerical data
  • Reproducibility of Results
  • Swine