Abstract
To test the reliability of amplitude-integrated electroencephalogram (aEEG) in cerebral hypoxic ischemia (HI), 12 neonatal piglets subjected to different levels of HI are divided into three groups based on the histological outcomes obtained 4 days after experiment. Results show that concomitant with the increased severity of brain injury, the upper and lower margins of aEEG decrease significantly (p < 0.05) during early recovery period after HI (about 2 hours post-resuscitation). We conclude that aEEG method reliably reflects hypoxic-ischemic cerebral injury and constitutes a valuable monitoring tool in neonatal intensive care unit (NICU).
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Animals, Newborn
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Asphyxia Neonatorum / diagnosis
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Biomedical Engineering
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Brain Injuries / diagnosis*
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Brain Injuries / pathology
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Brain Injuries / physiopathology
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Disease Models, Animal
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Electroencephalography / methods*
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Electroencephalography / statistics & numerical data
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Humans
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Hypoxia-Ischemia, Brain / diagnosis*
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Hypoxia-Ischemia, Brain / pathology
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Hypoxia-Ischemia, Brain / physiopathology
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Infant, Newborn
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Male
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Monitoring, Physiologic / methods
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Monitoring, Physiologic / statistics & numerical data
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Reproducibility of Results
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Swine