China started to pay more attention to regional and national health information network construction after the SARS epidemic outbreak in 2003. The Chinese government marks the public health system construction as the most urgent part of national medical reform, with information and computer technology (ICT) being considered as the key of deploying regional collaborative medical service (RCMS), which is also known as e-Health. In this paper, we firstly analyze the difficulties of carrying out e-health projects in China and then present the active attempts, finally a case representing current progress is presented and studied.