Synthesis and photoactivated insecticidal activity of tetraethynylsilanes

J Photochem Photobiol B. 2010 Jan 21;98(1):52-6. doi: 10.1016/j.jphotobiol.2009.11.003. Epub 2009 Nov 10.

Abstract

A series of tetraethynylsilanes (TETS) have been synthesized by reaction of silicon tetrachloride (SiCl(4)) with Ar-C triple bond CLi, which was prepared in situ by treatment of Ar-C triple bond CH with n-BuLi. For these TETS thus prepared, their photoactivated insecticidal activities against the 4th-instar larvae of Aedes albopictus (Skuse) were evaluated to enrich the structure-activity relationship. In particular, compound 8 exhibited excellent photoactivated insecticidal activity, the LC(50) value was 0.1346 mg L(-1) under UV light treatment and the irradiation-generated enhancement in the activity was more than 69.58-fold, thus could be exploitable as ideal analog candidates in the search for new photoactivated insecticide leads.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aedes / drug effects
  • Aedes / radiation effects
  • Animals
  • Insecticides / chemical synthesis*
  • Insecticides / chemistry
  • Insecticides / toxicity
  • Larva / drug effects
  • Larva / radiation effects
  • Light
  • Photosensitizing Agents / chemical synthesis*
  • Photosensitizing Agents / chemistry
  • Photosensitizing Agents / toxicity
  • Silanes / chemical synthesis*
  • Silanes / chemistry
  • Silanes / toxicity
  • Structure-Activity Relationship
  • Thiophenes / chemical synthesis*
  • Thiophenes / chemistry
  • Thiophenes / toxicity
  • Ultraviolet Rays

Substances

  • Insecticides
  • Photosensitizing Agents
  • Silanes
  • Thiophenes