Two new cytotoxic acetophenone derivatives from Euphorbia ebracteolata Hayata

Ning Zhang; Hao Cai; BaoChang Cai; HaiJun Yang; JunSong Li; GuangMing Yang

doi:10.1016/j.fitote.2009.11.007

Two new cytotoxic acetophenone derivatives from Euphorbia ebracteolata Hayata

Fitoterapia. 2010 Jul;81(5):385-8. doi: 10.1016/j.fitote.2009.11.007. Epub 2009 Dec 1.

Authors

Ning Zhang¹, Hao Cai, BaoChang Cai, HaiJun Yang, JunSong Li, GuangMing Yang

Affiliation

¹ Jiangsu Key Laboratory of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing, PR China.

PMID: 19958822
DOI: 10.1016/j.fitote.2009.11.007

Abstract

Two new acetophenone derivatives were isolated from the roots of Euphorbia ebracteolata Hayata, their structures were elucidated as 2,4-dihydroxy-6-methoxyl-methylene-3-methyl-acetophenone (1) and 2-dihydroxy-6-methoxyl-methylene-3-methyl-acetophenone-4-O-beta-D-glucopyranoside (2) on the basis of chemical and spectroscopic methods including (1)D- and (2)D-NMR techniques, and their cytotoxic activities were investigated by using the MTT method.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetophenones / chemistry
Acetophenones / pharmacology
Acetophenones / therapeutic use*
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology
Antineoplastic Agents, Phytogenic / therapeutic use*
Cell Line, Tumor
Euphorbia / chemistry*
HeLa Cells
Humans
Molecular Structure
Monosaccharides / chemistry
Monosaccharides / pharmacology
Monosaccharides / therapeutic use*
Neoplasms / drug therapy*
Phytotherapy
Plant Extracts / chemistry
Plant Extracts / pharmacology
Plant Extracts / therapeutic use*
Plant Roots

Substances

2,4-dihydroxy-6-methoxyl-methylene-3-methyl-acetophenone
2-dihydroxy-6-methoxyl-methylene-3-methyl-acetophenone-4-O-beta-D-glucopyranoside
Acetophenones
Antineoplastic Agents, Phytogenic
Monosaccharides
Plant Extracts