Noninvasive neonatal thymus graft into the axillary cavity extends the lifespan of old mice

Rejuvenation Res. 2010 Apr-Jun;13(2-3):288-91. doi: 10.1089/rej.2009.0936.

Abstract

Neonatal thymus grafts exert a rejuvenating action on various immunological and nonimmunological functions found altered in old mice. Commonly, half of a thymus is grafted under the kidney capsule. The invasiveness of the surgical procedure and the use of limited thymus tissue may explain why precedent survival kinetics remain unaffected. In this trial, we grafted two neonatal thymi into the axillary cavity of old mice, thus reducing the invasiveness of the intervention and increasing the amount of grafted neonatal tissue. Using a Piantanelli parametric model of survivorship, we found a significant change in mortality rate between the two groups (thymus graft and controls).

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Axilla
  • Longevity / physiology*
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Minimally Invasive Surgical Procedures / methods
  • Minimally Invasive Surgical Procedures / veterinary
  • Survival
  • Thymus Gland / growth & development
  • Thymus Gland / transplantation*
  • Time Factors
  • Transplantation, Heterotopic*
  • Up-Regulation