Reactogenicity and immunogenicity of combined Haemophilus influenzae type b-meningococcal serogroup C conjugate vaccine booster dose coadministered with measles, mumps, and rubella vaccine

Pediatr Infect Dis J. 2010 Mar;29(3):269-71. doi: 10.1097/INF.0b013e3181c15977.

Abstract

A booster dose of Haemophilus influenzae type b-Neisseria meningitidis serogroup C conjugate (Hib-MenC-TT) vaccine simultaneously administered with measles, mumps, and rubella (MMR) vaccine in 13- to 14-month-old Spanish toddlers, primed with 3 doses of a combined Diphteria-Tetanus-Acellular Pertusis DTPa-Hib-containing vaccine and a MenC-CRM197 conjugate vaccine, had a good reactogenicity profile and induced similar Hib and MenC booster responses and MMR seropositivity rates as the vaccines given alone.

Trial registration: ClinicalTrials.gov NCT00263653.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Bacterial / blood
  • Antibodies, Viral / blood
  • Drug-Related Side Effects and Adverse Reactions
  • Female
  • Haemophilus Vaccines / adverse effects*
  • Haemophilus Vaccines / immunology*
  • Humans
  • Immunization, Secondary / adverse effects*
  • Immunization, Secondary / methods
  • Infant
  • Male
  • Measles-Mumps-Rubella Vaccine / adverse effects*
  • Measles-Mumps-Rubella Vaccine / immunology*
  • Meningococcal Vaccines / adverse effects*
  • Meningococcal Vaccines / immunology*
  • Spain
  • Tetanus Toxoid / adverse effects*
  • Tetanus Toxoid / immunology*
  • Vaccines, Combined / adverse effects
  • Vaccines, Combined / immunology

Substances

  • Antibodies, Bacterial
  • Antibodies, Viral
  • Haemophilus Vaccines
  • Haemophilus influenza type b polysaccharide vaccine-tetanus toxin conjugate
  • Measles-Mumps-Rubella Vaccine
  • Meningococcal Vaccines
  • Tetanus Toxoid
  • Vaccines, Combined
  • serogroup C meningococcal conjugate vaccine

Associated data

  • ClinicalTrials.gov/NCT00263653